Veroni Sophia, Terzopoulou Kalliopi, Anagnostopoulou Irene, Vassilakaki Thivi, Grammatoglou Xanthippi, Rammou Rea
Department of Cytopathology, "Tzanio" General Hospital of Pireas, Afentouli and Zanni, 18536 Pireas, Greece.
Acta Cytol. 2010 Sep-Oct;54(5 Suppl):879-84.
Extraovarian peritoneal serous papillary carcinoma (EPSPC) is a rare cancer closely related to ovarian carcinoma and characterized by abdominal carcinomatosis without an identifiable abdominal primary tumor.
A woman presented with ascites. She had an elevated serum CA-125. Peritoneal carcinomatosis without involvement of the ovaries was found. Paracentesis of the ascitic fluid resulted in a positive cytologic report not further suggestive of the malignancy origin, balancing between a mesothelioma and an adenocarcinoma. The histologic and immunohistochemical study of peritoneal biopsy specimens resulted in the diagnosis of EPSPC.
The combination of cytology, histology, immunohistochemistry and clinical data is a reliable method for the preoperative diagnosis of EPSPC, allowing prompt chemotherapy as surgery may not be indicated in most cases.
卵巢外腹膜浆液性乳头状癌(EPSPC)是一种罕见的癌症,与卵巢癌密切相关,其特征是存在腹部癌性播散但未发现可识别的腹部原发性肿瘤。
一名女性出现腹水。她的血清CA-125升高。发现存在未累及卵巢的腹膜癌性播散。腹水穿刺获得的细胞学报告呈阳性,但未进一步提示恶性肿瘤的起源,难以区分是间皮瘤还是腺癌。腹膜活检标本的组织学和免疫组化研究确诊为EPSPC。
细胞学、组织学、免疫组化和临床资料相结合是术前诊断EPSPC的可靠方法,由于大多数情况下可能不适合手术,因此可据此及时进行化疗。