Interdisciplinary Doctoral Program in Evaluation, The Evaluation Center, Western Michigan University, 1903 W. Michigan Ave, Kalamazoo, MI, 49008-5237, USA.
J Psychoactive Drugs. 2010 Sep;42(3):339-46. doi: 10.1080/02791072.2010.10400696.
Methadone and buprenorphine are both efficacious treatments for opioid dependency, but they also have different pharmacological properties and clinical delivery methods that can affect their acceptability to patients. This study was intended to increase our knowledge of heroin-dependent individuals' perceptions of methadone vs. buprenorphine maintenance based on actual experiences with each. The study sample consists of heroin-dependent men at the Rikers Island jail in New York City who were voluntarily randomly assigned to methadone or buprenorphine maintenance in jail. Methadone patients were more likely to report feeling uncomfortable the first few days, having side/withdrawal effects during treatment, and being concerned about continued dependency on medication after release. In contrast, buprenorphine patients' main issue was the bitter taste. All of the buprenorphine patients stated that they would recommend the medication to others, with almost all preferring it to methadone. Ninety-three percent of buprenorphine vs. 44% of methadone patients intended to enroll in those respective treatments after release, with an added one-quarter of the methadone patients intending to enroll in buprenorphine instead. These results reinforce the importance of increasing access to buprenorphine treatment in the community for indigent heroin-dependent offenders.
美沙酮和丁丙诺啡都是有效的阿片类药物依赖治疗方法,但它们也具有不同的药理学特性和临床给药方法,这可能会影响患者的接受程度。本研究旨在增加我们对海洛因依赖者对美沙酮与丁丙诺啡维持治疗的看法的了解,这些看法基于他们对每种药物的实际经验。研究样本包括纽约市雷克岛监狱的男性海洛因依赖者,他们自愿随机分配到监狱中的美沙酮或丁丙诺啡维持治疗。美沙酮患者更有可能报告在最初几天感到不适、在治疗期间出现副作用/戒断症状,并担心释放后对药物的持续依赖。相比之下,丁丙诺啡患者的主要问题是味道苦。所有丁丙诺啡患者都表示会向他人推荐这种药物,几乎所有人都更喜欢丁丙诺啡而不是美沙酮。93%的丁丙诺啡患者和 44%的美沙酮患者打算在释放后参加各自的治疗,而四分之一的美沙酮患者打算转而参加丁丙诺啡治疗。这些结果强调了增加社区中对贫困海洛因依赖罪犯的丁丙诺啡治疗的重要性。