Dodani Sunita
Department of Internal Medicine, School of Medicine, University of Kansas Medical Center, 2308 W, 127 Street Leawood, Kansas, KS 66209, USA.
Inflamm Allergy Drug Targets. 2010 Dec;9(5):382-6. doi: 10.2174/187152810793938053.
South Asian Immigrants (SAIs) have high rates of coronary artery disease (CAD) and its risk factors. This is alarming as i) SAIs are the 2nd fastest growing Asian immigrant population in the US; ii) CAD prevalence is 2 times higher than in other immigrant populations; iii) at any risk factor level, SAIs are at a greater risk of CAD; and iv) Type 2 diabetes is a major risk factor and associated co-morbidity in SAIs. Although clinical guidelines for CAD prevention recommend risk management based on Framingham Risk Scores (FRS), available data suggest that FRS underestimate CAD risk in SAIs. This review presents an overview of platelet related research in SAIs, its importance in predicting CAD risk and methods of diagnosis. Further we provide discussion on the importance of platelet function assessment for more appropriate stratification of SAIs based on cardiovascular risk.
南亚移民（SAIs）患冠状动脉疾病（CAD）及其危险因素的比例较高。这令人担忧，原因如下：i）SAIs是美国增长第二快的亚洲移民群体；ii）CAD患病率比其他移民群体高两倍；iii）在任何危险因素水平下，SAIs患CAD的风险都更高；iv）2型糖尿病是SAIs的主要危险因素和相关合并症。尽管CAD预防临床指南建议根据弗雷明汉风险评分（FRS）进行风险管理，但现有数据表明FRS低估了SAIs患CAD的风险。本综述概述了SAIs中与血小板相关的研究、其在预测CAD风险中的重要性以及诊断方法。此外，我们还讨论了血小板功能评估对于根据心血管风险对SAIs进行更合理分层的重要性。
