School of Medicine, Eastern Virginia Medical School, Norfolk, VA, USA.
EVMS - Sentara Healthcare Analytics and Delivery Science Institute, Eastern Virginia Medical School, Norfolk, VA, USA.
J Racial Ethn Health Disparities. 2023 Jun;10(3):1194-1200. doi: 10.1007/s40615-022-01306-6. Epub 2022 Apr 21.
South Asians (SAs) account for a quarter of the world's population and are one of the fastest-growing immigrant groups in the United States (US). South Asian Immigrants (SAIs) are disproportionately more at risk of developing cardiovascular disease (CVD) than other ethnic/racial groups. Atherosclerosis is a chronic inflammatory disorder and is the major cause of CVD. Traditional CVD risk factors, though important, do not fully explain the elevated risk of CVD in SAIs. High-density lipoproteins (HDLs) are heterogeneous lipoproteins that modify their composition and functionality depending on physiological or pathological conditions. With its cholesterol efflux, anti-inflammatory, and antioxidant functions, HDL is traditionally considered a protective factor for CVD. However, its functions can be compromised under pathological conditions, such as chronic inflammation, making it dysfunctional (Dys-HDL). SAIs have a high prevalence of type 2 diabetes and metabolic syndrome, which may further promote Dys-HDL. This review explores the potential association between Dys-HDL and CVD in SAIs and presents current literature discussing the role of Dys-HDL in CVD.
南亚人（SAs）占世界人口的四分之一，是美国（US）增长最快的移民群体之一。南亚移民（SAIs）患心血管疾病（CVD）的风险比其他族裔/种族群体高得多。动脉粥样硬化是一种慢性炎症性疾病，是 CVD 的主要病因。传统的 CVD 风险因素虽然很重要，但不能完全解释 SAIs 中 CVD 风险的增加。高密度脂蛋白（HDLs）是异质脂蛋白，其组成和功能根据生理或病理条件而改变。HDL 通过胆固醇外排、抗炎和抗氧化作用，传统上被认为是 CVD 的保护因素。然而，在慢性炎症等病理条件下，其功能可能会受到损害，使其功能失调（Dys-HDL）。SAIs 患 2 型糖尿病和代谢综合征的患病率很高，这可能进一步促进 Dys-HDL。本综述探讨了 Dys-HDL 与 SAIs 中 CVD 之间的潜在关联，并介绍了目前讨论 Dys-HDL 在 CVD 中的作用的文献。
