Lu X, Lu D, Narayan U, Kakkar V V
Thrombosis Research Institute, Manresa Road, London, SW3 6LR UK.
Cardiovasc Hematol Agents Med Chem. 2011 Jan;9(1):25-41. doi: 10.2174/187152511794182819.
Atherosclerosis is rapidly gaining recognition as an inflammatory disease showing contribution from innate and adaptive immunity pathways towards disease initiation and progression. Components of adaptive immunity especially T cells, are shown to be involved in atherogenesis and subsets of T cells are known to drive/ dampen inflammatory processes in atherosclerosis. However, the regulatory balance between the T cell subsets remains unclear. In this review, we summarize the role of T helper cells Th1, 2, 3 and 17, and regulatory cells Treg in atherosclerosis by studying the cytokines involved in Th cell functioning. We further examine the diverse roles of T helper cells for regulating the progression of atherosclerosis.
动脉粥样硬化正迅速被公认为是一种炎症性疾病，先天免疫和适应性免疫途径均对疾病的发生和发展有影响。适应性免疫的组成部分尤其是T细胞，已被证明参与动脉粥样硬化的形成，并且已知T细胞亚群会驱动/抑制动脉粥样硬化中的炎症过程。然而，T细胞亚群之间的调节平衡仍不清楚。在本综述中，我们通过研究参与Th细胞功能的细胞因子，总结了辅助性T细胞Th1、Th2、Th3和Th17以及调节性细胞Treg在动脉粥样硬化中的作用。我们进一步探讨了辅助性T细胞在调节动脉粥样硬化进展中的多种作用。
