Department of Laboratory Medicine, University-Hospital of Padova, Via Giustiniani 2, Padua, Italy.
Helicobacter. 2010 Sep;15 Suppl 1:14-20. doi: 10.1111/j.1523-5378.2010.00781.x.
Helicobacter pylori infections are thought to eventually lead to symptoms as a result of the long-lasting interactions between the bacterium and its host. Mechanisms that allow this bacterium to cause a life-long infection involve modulation of both the immune response and host cellular processes. Last year many novel findings that improve our knowledge on how H. pylori virulence factors interact with the host were reported, but because of space limitations we can only discuss a limited number of these studies. Among those are studies on the genetic variation of genes encoding outer membrane proteins and the mimicry of host antigens, factors that alter host-cell metabolism and factors that modulate the host's immune response.
幽门螺杆菌感染被认为最终会导致症状，这是由于细菌与其宿主之间的长期相互作用。允许这种细菌引起终身感染的机制涉及对免疫反应和宿主细胞过程的调节。去年，许多新的发现提高了我们对幽门螺杆菌毒力因子与宿主相互作用的认识，但由于篇幅限制，我们只能讨论其中的少数几项研究。其中包括研究编码外膜蛋白的基因的遗传变异和宿主抗原的模拟、改变宿主细胞代谢的因素以及调节宿主免疫反应的因素。
