Exploring In Vitro the Combination of × L. and Mill. Extracts as Food Supplement Ingredients against Infection.

spp. have been traditionally used for inflammatory and infectious disorders, including gastrointestinal ailments, in the Mediterranean area. Among them, × L. is one of the most frequently cited species in the literature for a variety of biological activities which include inflammatory diseases. spp. aerial parts are rich in polyphenols such as condensed and hydrolysable tannins, procyanidins, and flavonoids, which show gastroprotective activities. The purpose of the present study is to investigate the biological activities of a hydroalcoholic extract from × L. aerial parts in gastric epithelial cells (GES-1) infected with . The extracts inhibited IL-8 and NF-κB induced by and showed antibacterial activity after simulated digestion. Since our previous paper reported interesting results on the ability of Mill. leaf extract to decrease inflammatory conditions in -infected gastric cells, the combination of and × extracts was also investigated, showing strong anti-inflammatory activity and inhibition of bacterial adhesion. This association of botanicals is proposed herein as a novel food supplement capable of counteracting gastric inflammatory conditions.