Martinelli Giulia, Fumagalli Marco, Pozzoli Carola, Nicotra Giovanna, Vicentini Silvia Francesca, Maranta Nicole, Sangiovanni Enrico, Dell'Agli Mario, Piazza Stefano
Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", University of Milan, 20133 Milan, Italy.
Estratti Piante Officinali EPO s.r.l., 20141 Milan, Italy.
Foods. 2023 Dec 21;13(1):40. doi: 10.3390/foods13010040.
spp. have been traditionally used for inflammatory and infectious disorders, including gastrointestinal ailments, in the Mediterranean area. Among them, × L. is one of the most frequently cited species in the literature for a variety of biological activities which include inflammatory diseases. spp. aerial parts are rich in polyphenols such as condensed and hydrolysable tannins, procyanidins, and flavonoids, which show gastroprotective activities. The purpose of the present study is to investigate the biological activities of a hydroalcoholic extract from × L. aerial parts in gastric epithelial cells (GES-1) infected with . The extracts inhibited IL-8 and NF-κB induced by and showed antibacterial activity after simulated digestion. Since our previous paper reported interesting results on the ability of Mill. leaf extract to decrease inflammatory conditions in -infected gastric cells, the combination of and × extracts was also investigated, showing strong anti-inflammatory activity and inhibition of bacterial adhesion. This association of botanicals is proposed herein as a novel food supplement capable of counteracting gastric inflammatory conditions.
在地中海地区，某些物种传统上被用于治疗炎症和感染性疾病，包括胃肠道疾病。其中，×L.是文献中因各种生物活性（包括炎症性疾病）而被最频繁引用的物种之一。某些物种的地上部分富含多酚类物质，如缩合单宁、可水解单宁、原花青素和黄酮类化合物，这些物质具有胃保护活性。本研究的目的是研究×L.地上部分的水醇提取物在感染幽门螺杆菌的胃上皮细胞（GES-1）中的生物活性。提取物抑制了幽门螺杆菌诱导的IL-8和NF-κB，并在模拟消化后显示出抗菌活性。由于我们之前的论文报道了关于Mill.叶提取物降低幽门螺杆菌感染的胃细胞炎症状态能力的有趣结果，因此还研究了Mill.提取物与×L.提取物的组合，结果显示出强大的抗炎活性和对细菌粘附的抑制作用。本文提出这种植物组合作为一种能够对抗胃部炎症状态的新型食品补充剂。
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