University Unit of Dermatology, University of Florence School of Medicine, Florence, Italy.
Dermatol Ther. 2010 Nov-Dec;23(6):597-605. doi: 10.1111/j.1529-8019.2010.01367.x.
Paraneoplastic syndromes are localized or diffuse pathologic manifestations that may occur in subjects affected by neoplastic diseases, even occult ones. Among the many clinical manifestations of paraneoplastic syndromes, cutaneous ones are quite common. It is estimated that skin manifestations may represent the very first diagnostic sign of a neoplastic disease in about 1% of patients. Many paraneoplastic syndromes with skin manifestations are caused by vascular alterations. In case of solid tumors, migrant thrombophlebitis and blood hypercoagulability can be seen, whereas in case of hematological neoplasms, vasculitis, and erythromelalgia can occur. Paraneoplastic vasculitis and paraneoplastic vascular syndromes are challenging issues in dermatology and general medicine. The present article will review the actual knowledge in the argument, together with providing hints for its diagnosis and management.
副肿瘤综合征是指发生于肿瘤患者，甚至隐匿性肿瘤患者的局部或弥漫性病理表现。在副肿瘤综合征的众多临床表现中，皮肤表现较为常见。据估计，约有 1%的患者皮肤表现可能是肿瘤疾病的最初诊断迹象。许多伴皮肤表现的副肿瘤综合征是由血管改变引起的。在实体肿瘤中，可出现游走性血栓性静脉炎和血液高凝状态，而在血液系统肿瘤中，可发生血管炎和红斑性肢痛症。副肿瘤性血管炎和副肿瘤性血管综合征是皮肤科和普通医学中的难题。本文将回顾该领域的现有知识，并提供诊断和治疗的提示。
