Division of Endocrinology, Diabetes & Metabolic Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Dermatol Ther. 2010 Nov-Dec;23(6):643-50. doi: 10.1111/j.1529-8019.2010.01369.x.
Endocrine and metabolic diseases, besides affecting other organs, can result in changes in cutaneous function and morphology and can lead to a complex symptomatology. Dermatologists may see some of these skin lesions first, either before the endocrinologist, or even after the internist or specialist has missed the right diagnosis. Because some skin lesions might reflect a life-threatening endocrine or metabolic disorder, identifying the underlying disorder is very important, so that patients can receive corrective rather than symptomatic treatment. In this issue, we will review various hormone-secreting tumors, including pituitary disorders (Cushing's syndrome and acromegaly), hyperthyroidism, glucagonoma, carcinoid syndrome, mastocytosis, and hyperandrogenism. We will focus on clinical manifestations, mainly cutaneous, followed by a brief discussion on how to make the diagnosis of each condition in addition to treatment options.
内分泌和代谢疾病除了影响其他器官外，还会导致皮肤功能和形态的变化，并导致复杂的症状。皮肤科医生可能会首先看到其中一些皮肤病变，要么早于内分泌学家，要么甚至在内科医生或专家错过了正确的诊断之后。由于一些皮肤病变可能反映出危及生命的内分泌或代谢紊乱，因此确定潜在的疾病非常重要，以便患者可以接受纠正性而不是对症治疗。在本期中，我们将回顾各种激素分泌肿瘤，包括垂体疾病（库欣综合征和肢端肥大症）、甲状腺功能亢进症、胰高血糖素瘤、类癌综合征、肥大细胞增多症和高雄激素血症。我们将重点介绍临床表现，主要是皮肤，然后简要讨论如何诊断每种疾病，以及治疗选择。
