Melanoma and Muscle-Cutaneous Sarcoma Division, European Institute of Oncology, Milan, Italy.
Dermatol Ther. 2010 Nov-Dec;23(6):651-61. doi: 10.1111/j.1529-8019.2010.01370.x.
Electroporation uses pulsed, high-intensity electric fields to temporarily increase cell membrane permeability by creation of pores, through which small molecules, such as chemotherapeutic agents, can diffuse inside cells before they reseal. The combination of electroporation with the administration of otherwise low-permeant cytotoxic drugs is known as electrochemotherapy (ECT). The two most commonly used drugs are bleomycin and cisplatin. ECT has already been proven to be effective in diverse tumor histotypes, including melanoma and basal and squamous cell carcinoma, Kaposi sarcoma, and breast cancer, also in those cases nonresponding to classical chemotherapies or other loco-regional treatment modalities, with a good safety profile. ECT can be proposed as loco-regional therapy for disseminated cutaneous and subcutaneous tumor lesions as alternative treatment modality to conventional therapies or as palliative care, in order to improve patients' quality of life.
电穿孔利用脉冲、高强度电场通过形成孔暂时增加细胞膜的通透性，使得小分子，如化疗药物，在重新封闭之前能够扩散到细胞内。电穿孔与其他低渗透性细胞毒性药物的联合应用被称为电化疗（ECT）。最常用的两种药物是平阳霉素和顺铂。ECT 已被证明在多种肿瘤组织学类型中有效，包括黑色素瘤以及基底细胞癌和鳞状细胞癌、卡波西肉瘤和乳腺癌，对于那些对经典化疗或其他局部区域治疗方法无反应的病例也有效，具有良好的安全性。ECT 可以作为局部区域治疗方法，用于治疗播散性皮肤和皮下肿瘤病变，作为传统疗法的替代治疗方法或姑息治疗，以提高患者的生活质量。
