Zhang Xue-mei, Zhang Wen-yan, Zhou Yuan-ping, Mo Xiang-lan, Li Yong-ping, Wang Gui-qiu, Zhou Ying-qiong, Zeng Si-en, Li Gan-di, Ye Hong-tao
Department of Pathology, the Fourth Affiliated Hospital, Guangxi Medical University, Liuzhou, China.
Zhonghua Bing Li Xue Za Zhi. 2010 Aug;39(8):513-7.
To study the genetic aberrations of ocular extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) type occurring in patients from southern China.
Fifty seven paraffin-embedded ocular MALT lymphoma specimens from patients in southern China were studied by interphase fluorescence-in-situ hybridization (FISH) for genetic aberrations including t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/IgH-bcl-10, t(14;18) (q32;q21)/IgH-MALT1 and bcl-6/FOXP1 gene translocations.
Amongst the 57 cases studied, 9 cases (15.8%) showed chromosome translocations, including 4 cases (7.0%) of t(11;18)(q21;q21)/API2-MALT1, 1 case (1.8%) of t(14;18) (q32;q21)/IgH-MALT1, 1 case (1.8%) of bcl-6 gene-related chromosome translocation and 3 cases (5.3%) of IgH-unknown translocation partner. FISH revealed 17 cases (29.8%) with 3 copies of bcl-6 gene, 21 cases (36.8%) with 3 copies of MALT1 gene and 12 cases (21.1%) with 3 copies of both genes.
The MALT lymphoma-associated chromosome translocations t(11;18)(q21;q21)/API2-MALT1 and t(14;18) (q32;q21)/IgH-MALT1 are demonstrated in ocular MALT lymphomas of southern Chinese patients. The prevalence is significantly different from that reported in northern Chinese and northern American patients, indicating a geographic heterogeneity in the MALT lymphoma-associated genetic aberrations. The presence of 3 copies of bcl-6 and MALT1 genes is the commonest genetic abnormalities observed in ocular MALT lymphomas, suggesting a possible role in MALT lymphomagenesis.
研究中国南方患者发生的黏膜相关淋巴组织（MALT）型眼外边缘区B细胞淋巴瘤的基因畸变情况。
采用间期荧光原位杂交（FISH）技术，对57例来自中国南方患者的石蜡包埋眼MALT淋巴瘤标本进行研究，检测包括t(11;18)(q21;q21)/API2-MALT1、t(1;14)(p22;q32)/IgH-bcl-10、t(14;18)(q32;q21)/IgH-MALT1和bcl-6/FOXP1基因易位在内的基因畸变。
在研究的57例病例中，9例（15.8%）显示染色体易位，其中4例（7.0%）为t(11;18)(q21;q21)/API2-MALT1，1例（1.8%）为t(14;18)(q32;q21)/IgH-MALT1，1例（1.8%）为bcl-6基因相关染色体易位，3例（5.3%）为IgH-未知易位伴侣。FISH检测发现17例（29.8%）存在3拷贝bcl-6基因，21例（36.8%）存在3拷贝MALT1基因，12例（21.1%）同时存在3拷贝这两个基因。
在中国南方患者的眼MALT淋巴瘤中证实了与MALT淋巴瘤相关的染色体易位t(11;18)(q21;q21)/API2-MALT1和t(14;18)(q32;q21)/IgH-MALT1。其发生率与中国北方和北美患者报道的情况有显著差异，表明MALT淋巴瘤相关基因畸变存在地域异质性。bcl-6和MALT1基因3拷贝的存在是眼MALT淋巴瘤中最常见的基因异常，提示其在MALT淋巴瘤发生中可能起作用。
