Wang Guan, Li Yan-fang
Department of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Science, Beijing 100029, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2010 Jul;38(7):618-20.
To explore the correlation between plasma level of lipoprotein(a) [Lp(a)] and coronary artery disease (CAD).
A total of 1011 patients underwent coronary angiography in our department from October 2007 to March 2009 due to chest pain were included, 613 cases (60.6%) were diagnosed as CAD and the remaining 398 non-CAD patients (39.4%) served as control. Lp(a), apolipoproteinA1 (apoA1), apolipoproteinB (apoB) were detected by immunoturbidimetry method, triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were measured by enzymatic approach. LDL-C/HDL-C ratio was calculated, multivariate logistic regression analysis was performed.
(1) The values of Lp(a), TG, TC, LDL-C and apoB, and the ratio of LDL-C/HDL-C in CAD group were significantly higher in CAD group [(170.00 ± 160.00) mg/L, (1.84 ± 0.90) mmol/L, (4.86 ± 0.88) mmol/L, (3.31 ± 0.72) mmol/L, (0.97 ± 0.17) mmol/L and 3.39 ± 0.93] compared to those in control group [(120.00 ± 100.00) mg/L, (1.67 ± 0.72) mmol/L, (4.61 ± 0.95) mmol/L, (2.96 ± 0.80) mmol/L, (0.90 ± 0.18) mmol/L and 2.89 ± 0.92, all P < 0.05]. (2) Multivariate logistic regression analysis (forward method) indicated that Lp(a) (OR = 16.201, 95%CI 3.477 - 75.489, P = 0.0001) was the most powerful independent risk factor for diagnosing coronary artery disease.
Lp(a) is the most powerful independent risk factors for diagnosing coronary artery disease.
探讨血浆脂蛋白(a)[Lp(a)]水平与冠状动脉疾病（CAD）之间的相关性。
纳入2007年10月至2009年3月因胸痛在我科接受冠状动脉造影的1011例患者，其中613例（60.6%）被诊断为CAD，其余398例非CAD患者（39.4%）作为对照。采用免疫比浊法检测Lp(a)、载脂蛋白A1（apoA1）、载脂蛋白B（apoB），采用酶法测定甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）。计算LDL-C/HDL-C比值，进行多因素logistic回归分析。
（1）CAD组的Lp(a)、TG、TC、LDL-C和apoB值以及LDL-C/HDL-C比值均显著高于对照组[（170.00±160.00）mg/L、（1.84±0.90）mmol/L、（4.86±0.88）mmol/L、（3.31±0.72）mmol/L、（0.97±0.17）mmol/L和3.39±0.93]，对照组分别为[（120.00±100.00）mg/L、（1.67±0.72）mmol/L、（4.61±0.95）mmol/L、（2.96±0.80）mmol/L、（0.90±0.18）mmol/L和2.89±0.92，均P<0.05]。（2）多因素logistic回归分析（向前法）表明，Lp(a)（OR=16.201，95%CI 3.477-75.489，P=0.0001）是诊断冠状动脉疾病最有力的独立危险因素。
Lp(a)是诊断冠状动脉疾病最有力的独立危险因素。
