Paracelus Medical University, Christian Doppler Klinik, Department of Neurology, Ignaz-Harrerstrasse 79, 5020 Salzburg, Austria.
Drug Discov Today. 2011 Jan;16(1-2):8-21. doi: 10.1016/j.drudis.2010.10.011. Epub 2010 Nov 3.
Multiple sclerosis (MS) is the most common chronic neurological disease in young adults in the western world. There was no specific treatment available for this serious disorder until the introduction of the immunomodulatory drug interferon-β in the mid-1990s. Since then, the number of agents and treatment strategies for MS has increased rapidly. Deeper knowledge on the heterogeneous nature of MS cleared the way for several more specific, more effective and more comfortable therapies. Here, because of the exciting recent developments concerning oral treatment forms for MS, we summarize the current state of approved and future therapy options. In particular, we highlight oral treatment options in MS.
多发性硬化症（MS）是西方世界中青年人群中最常见的慢性神经系统疾病。直到 20 世纪 90 年代中期免疫调节药物干扰素-β问世，这种严重疾病才没有有效的治疗方法。此后，MS 的药物种类和治疗策略迅速增加。对 MS 异质性本质的更深入了解为更具体、更有效、更舒适的治疗方法铺平了道路。在这里，由于最近关于 MS 口服治疗形式的令人兴奋的进展，我们总结了目前已批准和未来的治疗选择。特别是，我们强调了 MS 的口服治疗选择。
