Division of Clinical Pathology of University Hospital, Geneva, Switzerland.
Clin Liver Dis. 2010 Nov;14(4):651-68. doi: 10.1016/j.cld.2010.07.009.
Sinusoidal obstruction syndrome (SOS), formerly named venoocclusive disease, is a well-known complication of hematopoietic stem cell transplantation and ingestion of food or drinks contaminated by pyrrolizidine alkaloids. Many other drugs and toxins have been associated with SOS, including several chemotherapeutic agents and immunosuppressors. SOS contributes to significant morbidity and mortality in all these settings. This review describes the histologic lesions of SOS, details its pathogenesis as it is understood today, specifies the recent data on its causes and how it may influence clinical management of colorectal liver metastases, and discusses the current knowledge on diagnosis and preventive options.
窦状隙阻塞综合征（SOS），以前称为静脉阻塞性疾病，是造血干细胞移植和摄入被吡咯里西啶生物碱污染的食物或饮料的已知并发症。许多其他药物和毒素与 SOS 有关，包括几种化疗药物和免疫抑制剂。在所有这些情况下，SOS 都会导致严重的发病率和死亡率。本综述描述了 SOS 的组织学病变，详细说明了目前对其发病机制的理解，具体说明了最近关于其病因的资料以及它如何影响结直肠肝转移的临床管理，并讨论了目前关于诊断和预防选择的知识。
