Dept. of Internal Medicine I, Eberhard-Karls-University of Tuebingen, Otfried-Mueller-Str. 10, D-72076 Tuebingen, Germany.
Curr Biol. 2010 Nov 9;20(21):R940-2. doi: 10.1016/j.cub.2010.09.066.
Extracellular nucleotides have been reported to act as a 'find-me' signal in the context of phagocyte recruitment by apoptotically dying cells. A new study now examines the mechanisms of nucleotide release during apoptosis and describes the hemichannel-forming protein pannexin 1 as a crucial player in this scenario.
细胞外核苷酸被报道在凋亡细胞招募吞噬细胞的过程中作为一种“寻我”信号发挥作用。一项新的研究现在检查了细胞凋亡过程中核苷酸释放的机制，并将形成半通道的蛋白 pannexin 1 描述为该过程中的关键参与者。
