Department of Forensic Medicine, Chonbuk National University Medical School, Research Institute of Clinical Medicine and Institute for Medical Sciences, Jeonju, Jeonbuk 561-180, South Korea.
Hum Pathol. 2011 Feb;42(2):204-13. doi: 10.1016/j.humpath.2010.05.023. Epub 2010 Nov 5.
Recently, it has been reported that SIRT1 and DBC1 may be involved in the development of tumors and predict poor survival in some cancers. However, their exact role is not clear. Therefore, we investigated the expression status and clinical significance of DBC1 and SIRT1 expression in breast carcinomas. We evaluated the immunohistochemical expression of DBC1, SIRT1, and p53 using a 3-mm core from 122 patients with breast cancer for tissue microarray. Positive expression of DBC1 and SIRT1 were seen in 71% and 67% of patients, respectively. In the patients with breast cancer, overall, expression of DBC1 and SIRT1 was significantly associated with distant metastatic relapse and shorter relapse-free survival and overall survival by univariate analysis. Tumor stage and DBC1 and SIRT1 expression were also independent prognostic factors by multivariate analysis. Among the patients who had received chemotherapy, DBC1 and SIRT1 expression was significantly associated with distant metastatic relapse and shorter survival by univariate analysis. DBC1 expression was also associated with distant metastatic relapse and shorter survival in patients who had received endocrine therapy, according to univariate and multivariate analysis. In conclusion, this study shows that expression of DBC1 and SIRT1 is a significant prognostic indicator for breast carcinoma patients.
最近有报道称，SIRT1 和 DBC1 可能参与肿瘤的发生，并预测某些癌症的预后不良。然而，它们的确切作用尚不清楚。因此，我们研究了乳腺癌中 DBC1 和 SIRT1 表达的表达状态和临床意义。我们使用组织微阵列评估了 122 例乳腺癌患者的 3 毫米核心组织中 DBC1、SIRT1 和 p53 的免疫组织化学表达。在乳腺癌患者中，DBC1 和 SIRT1 的阳性表达率分别为 71%和 67%。在乳腺癌患者中，DBC1 和 SIRT1 的表达通过单因素分析与远处转移复发以及无复发生存期和总生存期较短显著相关。肿瘤分期以及 DBC1 和 SIRT1 的表达也是多因素分析的独立预后因素。在接受化疗的患者中，DBC1 和 SIRT1 的表达通过单因素分析与远处转移复发和生存期较短显著相关。根据单因素和多因素分析，DBC1 表达与接受内分泌治疗的患者的远处转移复发和生存期较短相关。总之，本研究表明，DBC1 和 SIRT1 的表达是乳腺癌患者的一个重要预后指标。
