Goto Taichiro, Maeshima Arafumi, Oyamada Yoshitaka, Wakaki Misa, Hamaguchi Reo, Kato Ryoichi
Department of General Thoracic Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
Ann Thorac Cardiovasc Surg. 2010 Aug;16(4):281-5.
The patient was a 75-year-old female with a history of no smoking. Under a diagnosis of lung cancer, she underwent a right lower lobectomy in March 2008. She was started on oral Uracil-Tegafur (UFT) (400 mg/day) from April and in May developed fatigue, respiratory discomfort, and tachycardiac atrial fibrillation. Chest X-ray film showed an increase in right pleural effusion. Thoracentesis revealed a yellowish, serous exudate containing predominantly lymphocytes, with no evidence of malignancy. Despite continued diuretic administration for 5 months from July, it was difficult to control the pleural effusion, and her activities of daily living remained low. In December of the same year, the oral administration of UFT was terminated, which 2 weeks later resulted in a marked decrease in pleural effusion on chest X-ray film. Respiratory discomfort and fatigue also subsided, and her general condition improved markedly. Herein we report a case of oral UFT-induced pleural effusion following lung cancer surgery.
该患者为75岁女性，无吸烟史。在被诊断为肺癌后，她于2008年3月接受了右下肺叶切除术。从4月开始口服替加氟尿嘧啶（UFT）（400毫克/天），5月出现疲劳、呼吸不适和快速性房性心律失常。胸部X光片显示右侧胸腔积液增加。胸腔穿刺抽出淡黄色浆液性渗出液，主要含淋巴细胞，未发现恶性证据。尽管从7月开始持续使用利尿剂5个月，但仍难以控制胸腔积液，她的日常生活活动能力仍然较低。同年12月，停止口服UFT，2周后胸部X光片显示胸腔积液明显减少。呼吸不适和疲劳也消退，她的总体状况明显改善。在此，我们报告一例肺癌手术后口服UFT引起胸腔积液的病例。
