Nagahiro Itaru, Miyamoto Manabu, Sugiyama Hironobu, Kawai Tsuyoshi, Toda Keisuke, Nobuhisa Tetsuharu, Endou Yoshikatsu, Watanabe Takanori, Matsumoto Yusuke, Watanabe Naoki, Kai Kyohei, Satou Shizou
Department of Surgery, Himeji Red Cross Hospital, Japan.
Gan To Kagaku Ryoho. 2011 Oct;38(10):1679-82.
A 68-year-old female received a left lower lobectomy for lung cancer (adenocarcinoma, pT2N1M0, stage II B). She had a postoperative bronchial fistula that was treated conservatively and cured. Two months after the operation, tegafur-uracil (UFT) 300 mg/day was initiated.She felt dyspnea on exertion after taking UFT for two weeks, and some infiltration shadows were observed on a chest X-ray two weeks later. A chest CT scan revealed unsegmental infiltration shadows at the intermediate areas of the right middle and lower lobes, and an air-bronchogram was observed inside of the shadows. A bronchoscopy was performed. Bronchoalveolar lavage revealed a high fraction rate of eosinophil(24%), and a transbronchial lung biopsy revealed infiltrations of lymphocytes, eosinophils and neutrophils into the intra-alveolar space. However, fibrosis of the alveolar wall was not observed. A drug-induced lymphocyte stimulation test was performed for UFT, resulting positive. She was diagnosed as drug-induced eosinopilic pneumonia due to UFT. After she discontinued UFT and started 30 mg/day of prednisolone, dyspnea and infiltrations on chest X-ray disappeared.
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