Kaminski M V, Williams S D
Division of Surgical Nutrition, University of Health Sciences, Chicago Medical School, IL.
Crit Care Med. 1990 Mar;18(3):327-35. doi: 10.1097/00003246-199003000-00018.
The theoretical basis for the rapid normalization of hypoalbuminemia is contingent on recognition of those clinical circumstances requiring rapid and prolonged repair of colloid oncotic pressure. Standard total parenteral nutrition (TPN) solutions repair serum protein only after prolonged periods of therapy. Nutritionists have empirically observed that adding albumin to TPN solutions can quickly normalize hypoalbuminemia for sustained periods. Infusion of similar quantities of albumin without TPN results in no prolonged normalization. The mechanism of the rapid normalization of serum albumin with albumin-modified TPN solutions has yet to be determined, as has its relationships to prevention of hypoalbuminemia-associated morbidity and mortality.
低白蛋白血症快速恢复正常的理论基础取决于对那些需要快速且长期修复胶体渗透压的临床情况的认识。标准的全胃肠外营养（TPN）溶液只有在长时间治疗后才能修复血清蛋白。营养学家通过经验观察发现，在TPN溶液中添加白蛋白可使低白蛋白血症在一段时间内迅速恢复正常。在没有TPN的情况下输注等量白蛋白并不能使低白蛋白血症长期恢复正常。白蛋白修饰的TPN溶液使血清白蛋白快速恢复正常的机制尚未确定，其与预防低白蛋白血症相关发病率和死亡率的关系也未明确。
