Shulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada.
Can J Neurol Sci. 2010 Nov;37(6):837-42. doi: 10.1017/s0317167100051532.
To describe the tumor characteristics and visual function in conservatively managed patients with non-functioning pituitary macroadenoma (NFMA) that contacted/compressed the visual pathway.
Retrospective case-series.
Tertiary-care academic institution.
Six patients with diagnosis of NFMA.
Visual function and radiological characteristics of the optic apparatus and pituitary tumor.
All patients had radiological evidence of optic apparatus compression but only one had visual field defect at the initial presentation. While two of the six patients developed visual field changes during followup (41±34.8 months), the patient with visual field defect at the time of diagnosis improved to normal vision.
Select NFMAs that contact the optic apparatus, without visual dysfunction, may be managed with close ophthalmological and radiographic monitoring, depending on tumor and imaging characteristics. This may be of particular relevance in patients considered to have a high peri-operative risk, such as advanced age or significant co-morbidities.
描述接触/压迫视路的非功能性垂体大腺瘤（NFMA）患者的肿瘤特征和视觉功能。
回顾性病例系列研究。
三级保健学术机构。
6 名 NFMA 患者。
视神经和垂体肿瘤的视觉功能和影像学特征。
所有患者均有视神经受压的影像学证据，但只有 1 例在初次就诊时出现视野缺损。在 6 名患者中，有 2 名在随访期间出现视野改变（41±34.8 个月），而在诊断时存在视野缺损的患者视力恢复正常。
对于接触视神经而无视觉功能障碍的选择 NFMA，可根据肿瘤和影像学特征，进行密切的眼科和影像学监测。对于那些被认为围手术期风险较高的患者，如高龄或存在严重合并症的患者，这可能尤其相关。
