Neuropaediatric Department, Paediatric Hospital, Christian-Albrechts-University, Schwanenweg 20, Kiel, Germany.
Cephalalgia. 2011 Apr;31(5):562-72. doi: 10.1177/0333102410388434. Epub 2010 Nov 8.
Migraine is a disorder of central information processing which may be characterized by increased amplitudes and reduced habituation of evoked and event-related potentials. In this pilot study, special behavioural training of habituation to aversive stimuli (MIPAS-Family = Migraine Patient Seminar for Families) was developed and proven effective in children suffering from migraine without aura.
13 children with migraine participated in the MIPAS-Family programme and 13 other children with migraine were treated with biofeedback. The influence of both treatments on abnormal cortical information processing in migraine was assessed using recordings of the contingent negative variation (CNV), an event-related slow cortical potential.
Both MIPAS training and biofeedback caused an equal reduction of migraine frequency and severity. However, MIPAS treatment was associated with a significant increase in iCNV habituation. Changes in the clinical course of migraine correlated positively with normalization of habituation: the greater the reduction in headache frequency, the greater the increase in CNV habituation was. These effects were not observed in the biofeedback group.
This study demonstrates that the specific treatment programme which was evolved from knowledge of pathogenetic mechanisms of migraine influences central information processing and leads to a clinical effect.
偏头痛是一种中枢信息处理障碍，其特征可能是诱发电位和事件相关电位的振幅增加和适应减少。在这项初步研究中，针对厌恶刺激适应的特殊行为训练（MIPAS-Family=偏头痛患者家庭研讨会）被开发出来，并已被证明对无先兆偏头痛的儿童有效。
13 名偏头痛患儿参加了 MIPAS-Family 项目，另有 13 名偏头痛患儿接受了生物反馈治疗。使用事件相关慢电位中的条件负变（CNV）来评估两种治疗方法对偏头痛患者异常皮质信息处理的影响。
MIPAS 训练和生物反馈都能使偏头痛的发作频率和严重程度同等降低。然而，MIPAS 治疗与 iCNV 适应的显著增加有关。偏头痛临床病程的变化与适应的正常化呈正相关：头痛发作频率降低越多，CNV 适应的增加越大。这些效果在生物反馈组中没有观察到。
本研究表明，源自偏头痛发病机制知识的特定治疗方案影响中枢信息处理，并产生临床效果。
