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关联性负变——偏头痛的研究结果与展望

Contingent negative variation--findings and perspectives in migraine.

作者信息

Kropp P, Gerber W D

机构信息

Department of Medical Psychology, University of Kiel, Germany.

出版信息

Cephalalgia. 1993 Feb;13(1):33-6. doi: 10.1046/j.1468-2982.1993.1301033.x.

DOI:10.1046/j.1468-2982.1993.1301033.x
PMID:8448786
Abstract

Contingent negative variation (CNV) is a negative cerebral potential which is related to attention and arousal. CNV occurs during an experimental situation in which stimuli and responses are serially organized. Between attacks migraine patients have on average higher negative amplitudes compared to healthy controls or patients with tension-type headache. Successful treatment with beta-blocking agents decreases CNV amplitudes. In spite of encouraging findings in neurological disorders, CNV is not widely used. In this review some possible reasons for this are pointed out.

摘要

关联性负变(CNV)是一种与注意力和觉醒相关的负性脑电位。CNV出现在刺激和反应按顺序组织的实验情境中。在发作间期,偏头痛患者的负性波幅平均高于健康对照组或紧张型头痛患者。使用β受体阻滞剂成功治疗可降低CNV波幅。尽管在神经系统疾病中取得了令人鼓舞的发现,但CNV并未得到广泛应用。在这篇综述中指出了一些可能的原因。

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1
Contingent negative variation--findings and perspectives in migraine.关联性负变——偏头痛的研究结果与展望
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Is increased amplitude of contingent negative variation in migraine due to cortical hyperactivity or to reduced habituation?偏头痛中关联性负变的波幅增加是由于皮质活动亢进还是由于习惯化减弱?
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引用本文的文献

1
Unveiling the Role of Contingent Negative Variation (CNV) in Migraine: A Review of Electrophysiological Studies in Adults and Children.揭示关联性负变(CNV)在偏头痛中的作用:成人和儿童电生理研究综述
Biomedicines. 2023 Nov 11;11(11):3030. doi: 10.3390/biomedicines11113030.
2
Exploring the cortical habituation in migraine patients based on contingent negative variation.基于关联性负变探讨偏头痛患者的皮质习惯化。
Front Neurol. 2023 Aug 30;14:1226554. doi: 10.3389/fneur.2023.1226554. eCollection 2023.
3
Effects of Electroacupuncture Combined With Psychological Intervention on Depressive Status and Contingent Negative Variation in Patients With Internet Addiction Disorder: A Randomized Controlled Trial.
电针联合心理干预对网络成瘾障碍患者抑郁状态及关联性负变的影响:一项随机对照试验
Front Psychiatry. 2021 Nov 15;12:722422. doi: 10.3389/fpsyt.2021.722422. eCollection 2021.
4
Habituation and sensitization in primary headaches.原发性头痛的习惯化和敏化。
J Headache Pain. 2013 Jul 30;14(1):65. doi: 10.1186/1129-2377-14-65.
5
Beta-blocker migraine prophylaxis affects the excitability of the visual cortex as revealed by transcranial magnetic stimulation.β受体阻滞剂偏头痛预防作用的经颅磁刺激研究。
J Headache Pain. 2012 Jan;13(1):83-9. doi: 10.1007/s10194-011-0401-x. Epub 2011 Nov 17.
6
[Migraine: a disorder of sensory stimulus modulation? Empirical studies based on contingent negative variation.].[偏头痛:一种感觉刺激调制障碍?基于关联性负变的实证研究。]
Schmerz. 1993 Dec;7(4):280-6. doi: 10.1007/BF02529864.
7
Influence of aspirin on the contingent negative wave in healthy subjects.
Neurosci Behav Physiol. 1996 Sep-Dec;26(5):489-91. doi: 10.1007/BF02359412.