Zoll Whitney M, Miller Andrew D, Bandt Carston, Abbott Jeffrey R
Antech Diagnostics, College Station, TX (Zoll).
Department of Biomedical Sciences, Section of Anatomic Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY (Miller).
J Vet Diagn Invest. 2019 Jan;31(1):94-97. doi: 10.1177/1040638718822683.
A 15-y-old neutered male domestic shorthaired cat was presented with a 16-d history of hindlimb paralysis in conjunction with 1-wk duration of inappetence and lethargy. Given intractable clinical signs, development of seizures, and poor prognosis, euthanasia was elected. Gross examination revealed mild, chronic, multifocal intervertebral disk disease; however, no gross abnormalities were noted in the spinal cord. Histologic examination of the cervical, thoracic, and lumbar spinal cord and the myelencephalon revealed diffuse and variable expansion of the meninges by sheets of neoplastic round-to-polygonal cells. The cells formed sheets and clusters, supported by a variably eosinophilic, fibrillar-to-basophilic, homogeneous matrix, and contained a small amount of eosinophilic cytoplasm. The nuclei were round with finely stippled to hyperchromatic chromatin and 1-2 small nucleoli. Mild white matter degeneration was present in the dorsal and ventral funiculi multifocally throughout the spinal cord, but was most severe in the ventral lumbar sections. Immunohistochemistry revealed strong intranuclear immunoreactivity for Olig2, and intracytoplasmic immunoreactivity for glial fibrillary acidic protein, MAP2, and vimentin in the neoplastic glial cells. To our knowledge, primary leptomeningeal gliomatosis has not been reported previously in a cat.
一只15岁已绝育的雄性家养短毛猫，出现后肢麻痹16天，同时伴有1周的食欲不振和嗜睡。鉴于临床症状难以控制、出现癫痫发作且预后不良，选择实施安乐死。大体检查发现轻度、慢性、多灶性椎间盘疾病；然而，脊髓未发现明显异常。对颈髓、胸髓、腰髓和延髓进行组织学检查，发现肿瘤性圆形至多边形细胞片使脑膜弥漫性、不同程度地扩张。这些细胞形成片状和簇状，由嗜酸性、纤维状至嗜碱性、均匀的基质支持，含有少量嗜酸性细胞质。细胞核圆形，染色质呈细颗粒状至深染，有1 - 2个小核仁。脊髓背侧和腹侧索多处出现轻度白质变性，腰段腹侧最为严重。免疫组化显示肿瘤性神经胶质细胞中Olig2呈强核内免疫反应性，胶质纤维酸性蛋白、微管相关蛋白2和波形蛋白呈胞质内免疫反应性。据我们所知，猫原发性软脑膜胶质瘤病此前未见报道。
