Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA.
Hypertension. 2010 Dec;56(6):1118-23. doi: 10.1161/HYPERTENSIONAHA.110.158329. Epub 2010 Nov 8.
The purpose of this study was to evaluate the relationship between the cardiac and sympathetic baroreflex sensitivities within healthy, young humans. The sensitivities of the cardiac and sympathetic baroreflexes were compared in 53 normotensive individuals (28 men and 25 women; age: 24.0 ± 0.9 years; body mass index: 24.0 ± 0.3 cm/kg², mean ± SEM). Heart rate, arterial blood pressure, and peroneal muscle sympathetic nerve activity were recorded under resting conditions (heart rate: 58 ± 1 bpm; systolic blood pressure: 126 ± 2 mm Hg; diastolic blood pressure: 72 ± 1 mm Hg; mean arterial blood pressure: 89 ± 1 mm Hg; muscle sympathetic nerve activity: 18 ± 1 bursts per min) and during rapid changes in blood pressure induced by sequential boluses of nitroprusside and phenylephrine. Cardiac and sympathetic baroreflex sensitivities were analyzed using the slopes of the linear portions of the muscle sympathetic nerve activity-diastolic blood pressure and R-R interval-systolic blood pressure relationships, respectively. When individual cardiac baroreflex sensitivity was compared with sympathetic baroreflex sensitivity, no correlation (R-R interval: r = -0.13; heart rate: r = 0.21) was observed when studied as a group. Analysis by sex unveiled a correlation in women between the cardiac and sympathetic baroreflex sensitivities (R-R interval: r = -0.54; P = 0.01; no correlation with hazard ratio: r = 0.29). No relationship was found in men (R-R interval: r = 0.17; heart rate: r = 0.12). These results indicate that, although both cardiac and sympathetic efferents function in baroreflex control of arterial pressure, there is no correlation in their sensitivities within healthy normotensive humans. However, sex-stratified data indicate that sex-based differential correlations might exist.
这项研究的目的是评估健康年轻人群中心脏和交感神经压力反射敏感性之间的关系。在 53 名血压正常的个体（28 名男性和 25 名女性；年龄：24.0±0.9 岁；体重指数：24.0±0.3cm/kg²，平均值±SEM）中比较了心脏和交感神经压力反射的敏感性。在休息状态下（心率：58±1bpm；收缩压：126±2mmHg；舒张压：72±1mmHg；平均动脉压：89±1mmHg；肌肉交感神经活动：18±1 次/分钟）和通过硝普盐和苯肾上腺素序贯推注快速改变血压期间记录心率、动脉血压和腓肠肌交感神经活动。使用肌肉交感神经活动-舒张压和 R-R 间期-收缩压关系的线性部分的斜率分别分析心脏和交感神经压力反射敏感性。当将个体心脏压力反射敏感性与交感神经压力反射敏感性进行比较时，作为一个群体进行研究时，两者之间没有相关性（R-R 间期：r=-0.13；心率：r=0.21）。按性别分析显示，女性的心脏和交感神经压力反射敏感性之间存在相关性（R-R 间期：r=-0.54；P=0.01；与危险比无相关性：r=0.29）。在男性中未发现相关性（R-R 间期：r=0.17；心率：r=0.12）。这些结果表明，尽管心脏和交感传出神经在动脉压的压力反射控制中起作用，但在健康的血压正常人群中，它们的敏感性没有相关性。然而，按性别分层的数据表明，可能存在基于性别的差异相关性。
