Adachi M, Tefferi A, Greipp P R, Kipps T J, Tsujimoto Y
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104.
J Exp Med. 1990 Feb 1;171(2):559-64. doi: 10.1084/jem.171.2.559.
Most of human follicular lymphomas possess the t(14;18) chromosome translocation that juxtaposes the IgH gene to the 3' region of bcl-2 in a head-to-tail configuration. Here we show that the rearrangement of the bcl-2 gene occurs in a significant fraction (approximately of 10%) of B cell CLL. In all cases analyzed, breakpoints on chromosome 18 clustered at the 5' flanking region of the bcl-2 gene, and no rearrangements were found at the major or minor breakpoint clustering region (3' region of bcl-2 gene) typical of the t(14;18) chromosome translocation. All of the rearranged bcl-2 genes were juxtaposed with the Ig lambda or K genes in a head-to-head configuration. These results imply that the bcl-2 gene is preferentially linked to the IgL genes in CLL and could function in leukemogenesis.
大多数人类滤泡性淋巴瘤存在t(14;18)染色体易位，该易位使IgH基因与bcl-2基因的3'区域以头对头的方式并列。在此我们表明，bcl-2基因重排在相当一部分（约10%）的B细胞慢性淋巴细胞白血病（CLL）中出现。在所有分析的病例中，18号染色体上的断点聚集在bcl-2基因的5'侧翼区域，在典型的t(14;18)染色体易位的主要或次要断点聚集区域（bcl-2基因的3'区域）未发现重排。所有重排的bcl-2基因都与Igλ或K基因以头对头的方式并列。这些结果表明，在CLL中bcl-2基因优先与IgL基因相连，并可能在白血病发生过程中发挥作用。
