Adachi M, Imai K, Yachi A, Tsujimoto Y
First Department of Internal Medicine, Sapporo Medical College.
Rinsho Ketsueki. 1991 Jun;32(6):650-4.
Most of human follicular lymphomas (approximately 90% in U.S.A. or approximately 30% in Japan) possess the t(14; 18) chromosome translocation that directly involves the IgH locus on chromosome 14 and the bcl-2 gene on chromosome 18. The t(14; 18) chromosome translocation occurs nearly exclusively at two hot spots, a major breakpoint clustering region (mbr) within the 2nd exon noncoding region and the minor breakpoint clustering region (mcr) within the 3' flanking region of the bcl-2 gene. Here we show that the rearrangement of the bcl-2 gene occurs in a significant fraction (approximately 10%) of B-CLL. All of the rearranged bcl-2 genes were juxtaposed with Ig lambda or Ig kappa genes, implying that the bcl-2 gene is preferentially linked to the IgL genes in CLL.
大多数人类滤泡性淋巴瘤（在美国约占90%，在日本约占30%）具有t(14; 18)染色体易位，该易位直接涉及14号染色体上的免疫球蛋白重链（IgH）基因座和18号染色体上的bcl-2基因。t(14; 18)染色体易位几乎只发生在两个热点区域，即bcl-2基因第2外显子非编码区内的主要断裂点聚集区（mbr）和bcl-2基因3'侧翼区内的次要断裂点聚集区（mcr）。我们在此表明，bcl-2基因重排在相当一部分（约10%）的B细胞慢性淋巴细胞白血病（B-CLL）中发生。所有重排的bcl-2基因都与免疫球蛋白λ（Ig lambda）或免疫球蛋白κ（Ig kappa）基因并列，这意味着在慢性淋巴细胞白血病中bcl-2基因优先与免疫球蛋白轻链（IgL）基因相连。
