Ochs M W, Tucker M R, Owsley T G, Anderson J A
University of Florida, Gainesville.
J Oral Maxillofac Surg. 1990 Mar;48(3):240-5. doi: 10.1016/0278-2391(90)90387-h.
In this double-blind study 31 outpatients undergoing third molar extraction were randomly assigned to one of two groups. All patients were sedated with intravenous midazolam (IV) by titration method. The flumazenil group (n = 20) received an average of 0.8 +/- 0.17 mg of flumazenil IV. The placebo patients (n = 11) each received 10 mL of normal saline. By both observer and patient alertness ratings, patients receiving flumazenil appeared significantly more alert than placebo patients at 5, 15, 30, and 60 minutes following reversal. After reversal the flumazenil group had significantly higher scores than the placebo group at all intervals through 60 minutes. All the patients receiving flumazenil were able to walk without assistance at 5 minutes, compared with only one patient in the placebo group, and more patients in the flumazenil group recognized the picture card shown to them at 5, 15, 30, and 60 minutes postreversal. Flumazenil is effective in terminating the amnestic properties of midazolam, but this appears to occur to a lesser extent than the reversal of its sedative properties.
在这项双盲研究中，31名接受第三磨牙拔除术的门诊患者被随机分为两组。所有患者均通过滴定法静脉注射咪达唑仑进行镇静。氟马西尼组（n = 20）平均静脉注射0.8±0.17 mg氟马西尼。安慰剂组患者（n = 11）每人接受10 mL生理盐水。通过观察者和患者的清醒程度评分，在苏醒后的5、15、30和60分钟，接受氟马西尼的患者比安慰剂组患者明显更清醒。苏醒后，氟马西尼组在60分钟内的所有时间段得分均显著高于安慰剂组。所有接受氟马西尼的患者在5分钟时能够独立行走，而安慰剂组只有一名患者可以，并且氟马西尼组有更多患者在苏醒后的5、15、30和60分钟识别出向他们展示的图片卡片。氟马西尼可有效消除咪达唑仑的遗忘作用，但这一作用似乎比其镇静作用的逆转程度要小。
