Thomson P J, Coulthard P, Snowdon A T, Mitchell K
Department of Oral and Maxillofacial Medicine and Surgery, Turner Dental School, University of Manchester.
Br J Oral Maxillofac Surg. 1993 Apr;31(2):101-3. doi: 10.1016/0266-4356(93)90170-2.
A total of 40 patients receiving intravenous midazolam for surgical removal of impacted wisdom teeth were randomly assigned to recover either spontaneously or undergo reversal by the benzodiazepine antagonist flumazenil. Whilst initial postoperative recovery to a 'fully awake' state occurred more rapidly in the reversal group, objective psychomotor testing revealed significantly poorer performance postoperatively compared with spontaneously recovering patients; this emphasises the need to retain patients for at least 1 h prior to discharge home.
共有40例接受静脉注射咪达唑仑以手术拔除阻生智齿的患者被随机分配，分别自主恢复或使用苯二氮䓬拮抗剂氟马西尼进行逆转。虽然逆转组术后恢复到“完全清醒”状态的速度更快，但客观的精神运动测试显示，与自主恢复的患者相比，术后表现明显较差；这强调了在出院回家前将患者留观至少1小时的必要性。
