Masihi K N, Lange W, Rohde-Schulz B
Robert Koch Institute, Federal Health Office, Berlin, F.R.G.
J Acquir Immune Defic Syndr (1988). 1990;3(3):200-5.
Common bacterial infections are increasingly being diagnosed in HIV-infected individuals. Cells of the monocyte-macrophage lineage kill invading bacterial pathogens and subsequently release immunoadjuvant components from the degraded cell walls. Since monocytes can be infected with HIV, effects of bacterial immunomodulators on infected promonocytic U937 cells were investigated. Synthetic muramyl peptide, mycobacterial trehalose dimycolate, and detoxified endotoxin exhibited an initial reduction followed by a rapid increase in HIV p24 antigen production. The upregulation of virus expression was correlated with enhanced interleukin-1 beta levels and a decrease in TNF-alpha production.
在艾滋病毒感染者中，常见细菌感染的诊断越来越多。单核细胞 - 巨噬细胞谱系的细胞会杀死入侵的细菌病原体，随后从降解的细胞壁中释放免疫佐剂成分。由于单核细胞可被艾滋病毒感染，因此研究了细菌免疫调节剂对感染的前单核细胞U937细胞的影响。合成的胞壁酰肽、分枝杆菌海藻糖二霉菌酸酯和解毒内毒素最初会使艾滋病毒p24抗原产量降低，随后迅速增加。病毒表达的上调与白细胞介素 - 1β水平的升高以及肿瘤坏死因子 - α产量的降低相关。
