肿瘤坏死因子在分枝杆菌海藻糖二霉菌酸酯（索状因子）的抗肿瘤活性中的作用。
Participation of tumor necrosis factor in the antitumor activity of mycobacterial trehalose dimycolate (cord factor).
作者信息
Silva C L
机构信息
Departamento de Parasitologia, Microbiologia e Imunologia, Faculdade de Medicina de Ribeiräo Preto, Universidade de Säo Paulo, Brasil.
出版信息
Braz J Med Biol Res. 1989;22(3):341-4.
Trehalose dimycolate, a mycobacterial glycolipid also known as cord factor, retains some of the antitumor properties of the intact BCG. Murine macrophages incubated in vitro in the presence of trehalose dimycolate for 20 h at 37 degrees C released a factor which was cytotoxic for the L929 tumor cell line. Anti-tumor necrosis factor (TNF) blocked the cytotoxicity of trehalose dimycolate macrophage supernatant. Therefore the antitumor activity of trehalose dimycolate can be attributed to TNF released in the in vitro assay.
海藻糖二霉菌酸酯，一种也被称为索状因子的分枝杆菌糖脂，保留了完整卡介苗的一些抗肿瘤特性。在37摄氏度下，于海藻糖二霉菌酸酯存在的情况下体外孵育20小时的小鼠巨噬细胞释放出一种对L929肿瘤细胞系具有细胞毒性的因子。抗肿瘤坏死因子（TNF）阻断了海藻糖二霉菌酸酯巨噬细胞上清液的细胞毒性。因此，海藻糖二霉菌酸酯的抗肿瘤活性可归因于体外试验中释放的TNF。
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