Fujikura Terumichi, Okubo Kimihiro
Department of Head & Neck and Sensory Organ Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
J Nippon Med Sch. 2010 Oct;77(5):273-6. doi: 10.1272/jnms.77.273.
Myoepithelioma is a rare neoplasm that can occur in either the major or minor salivary gland and accounts for less than 1% of salivary gland neoplasms. We report a rare case of a nasal myoepithelioma that originated from the nasal inferior turbinate. The tumor, measuring 50 × 30 × 20 mm, was in the right nasal cavity and had a necrotic surface. We removed the tumor through endonasal endoscopic surgery. The tumor had spindle-shaped cells and was positive for cytokeratin, (AE1/AE3), vimentin, S-100β, and MIB-1 but was negative for CD34, desmin, neuron-specific enolase, and synaptophysin. Slight immunoreactivity for smooth muscle actin was noted in some tumor cells. There has been no evidence of tumor recurrence in the 18 months following surgery.
肌上皮瘤是一种罕见的肿瘤，可发生于大唾液腺或小唾液腺，占唾液腺肿瘤的比例不到1%。我们报告一例罕见的起源于鼻下鼻甲的鼻腔肌上皮瘤。肿瘤大小为50×30×20mm，位于右侧鼻腔，表面有坏死。我们通过鼻内镜手术切除了肿瘤。肿瘤细胞呈梭形，细胞角蛋白（AE1/AE3）、波形蛋白、S-100β和MIB-1呈阳性，但CD34、结蛋白、神经元特异性烯醇化酶和突触素呈阴性。部分肿瘤细胞可见平滑肌肌动蛋白轻度免疫反应性。术后18个月无肿瘤复发迹象。
