M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Moscow 142782, Russia.
Nat Rev Microbiol. 2010 Dec;8(12):867-78. doi: 10.1038/nrmicro2452. Epub 2010 Nov 9.
Interactions with host defences are key aspects of viral infection. Various viral proteins perform counter-defensive functions, but a distinct class, called security proteins, is dedicated specifically to counteracting host defences. Here, the properties of the picornavirus security proteins L and 2A are discussed. These proteins have well-defined positions in the viral polyprotein, flanking the capsid precursor, but they are structurally and biochemically unrelated. Here, we consider the impact of these two proteins, as well as that of a third security protein, L(*), on viral reproduction, pathogenicity and evolution. The concept of security proteins could serve as a paradigm for the dedicated counter-defensive proteins of other viruses.
与宿主防御的相互作用是病毒感染的关键方面。各种病毒蛋白具有拮抗防御的功能,但一类称为“安全蛋白”的特殊蛋白专门用于拮抗宿主防御。本文讨论了小核糖核酸病毒的安全蛋白 L 和 2A 的特性。这些蛋白在病毒多蛋白中具有明确的位置,位于衣壳前体的两侧,但它们在结构和生化上没有关联。在这里,我们考虑了这两种蛋白以及第三种安全蛋白 L(*) 对病毒繁殖、致病性和进化的影响。安全蛋白的概念可以作为其他病毒专门拮抗防御蛋白的范例。