Cell Motility Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
Microbes Infect. 2009 Nov;11(13):1071-8. doi: 10.1016/j.micinf.2009.08.012. Epub 2009 Sep 4.
Many viruses regulate a crucial point in the apoptotic pathway by expressing viral Bcl-2 homologues, which have become useful tools to investigate the mechanisms behind the control of the mitochondrial checkpoint of apoptosis. Concurrently, a number of viral inhibitors of innate immune signalling have been instrumental tools in the discovery of key host pathways. Here we discuss how viral inhibitors of the apoptotic and innate signalling pathways have further enhanced the understanding of both research fields and are beginning to shed light on how these two pathways converge.
许多病毒通过表达病毒 Bcl-2 同源物来调节细胞凋亡途径中的一个关键节点，这些同源物已成为研究线粒体凋亡检查点调控机制的有用工具。同时，许多病毒先天免疫信号通路抑制剂已成为发现关键宿主通路的重要工具。在这里，我们讨论了凋亡和先天信号通路的病毒抑制剂如何进一步增强了对这两个研究领域的理解，并开始揭示这两条通路是如何交汇的。
