Rosen D L, Pendleton J D
Appl Opt. 1995 Sep 1;34(25):5875-84. doi: 10.1364/AO.34.005875.
Light scattered from optically active spheres was theoretically analyzed for biodetection. The circularly polarized signal of near-forward scattering from circularly dichroic spheres was calculated. Both remote and point biodetection were considered. The analysis included the effect of a circular aperture and beam block at the detector. If the incident light is linearly polarized, a false signal would limit the sensitivity of the biodetector. If the incident light is randomly polarized, shot noise would limit the sensitivity. Suggested improvements to current techniques include a beam block, precise angular measurements, randomly polarized light, index-matching fluid, and larger apertures for large particles.
为了生物检测，对从旋光球体散射的光进行了理论分析。计算了来自圆二色性球体的近前向散射的圆偏振信号。考虑了远程和点生物检测。分析包括探测器处圆形孔径和光束阻挡的影响。如果入射光是线偏振的，虚假信号会限制生物探测器的灵敏度。如果入射光是随机偏振的，散粒噪声会限制灵敏度。对当前技术的改进建议包括光束阻挡、精确的角度测量、随机偏振光、折射率匹配液以及针对大颗粒的更大孔径。
