Moise Duane, Singh Jaspreet, Dahl Keith, Rashid Sadat, Prasad Apsara, Siddiqui Ghulam, Subramani Krishnaiyer, Mustacchia Paul, Rizvon Kaleem
Department of Gastroenterology, Nassau University Medical Center, East Meadow, N.Y., USA.
Case Rep Gastroenterol. 2010 Aug 27;4(2):298-303. doi: 10.1159/000314821.
Extrapulmonary small cell carcinoma of the stomach is a rare and aggressive malignancy with a poor prognosis that was first described in 1976 by Matsusaka et al. In 1989 it was recognized by the World Health Organization as an independent entity affecting the stomach. Pure and composite are the two types of gastric small cell carcinoma reported in the literature. We report a case of a 68-year-old African American male with metastatic pure-type extrapulmonary small cell cancer of the stomach. The primary lesion measured approximately 7 cm in diameter on endoscopy. The diagnosis was made on the basis of characteristic histological features of small, round, oval lymphocyte-like cells with hyperchromatic nuclei, and scant cytoplasm consistent with small cell carcinoma. Gastric small cell carcinoma is typically diagnosed at an advanced stage as demonstrated in our case. We conducted a literature review discussing the two types of extrapulmonary small cell carcinoma of the stomach and their prevalence.
胃肺外小细胞癌是一种罕见且侵袭性强的恶性肿瘤，预后较差，1976年由松坂等人首次描述。1989年，世界卫生组织将其认定为一种影响胃部的独立实体。文献报道的胃小细胞癌有纯型和复合型两种类型。我们报告一例68岁非裔美国男性，患有转移性胃纯型肺外小细胞癌。内镜检查显示原发灶直径约7厘米。诊断依据是具有特征性组织学特征，即小的、圆形、椭圆形淋巴细胞样细胞，核深染，胞质稀少，符合小细胞癌。如我们的病例所示，胃小细胞癌通常在晚期才被诊断出来。我们进行了文献综述，讨论了胃肺外小细胞癌的两种类型及其患病率。
