Sen Rajeev, Bhutani Namita, Saini Reeti
Deptt. of Pathology, PGIMS Rohtak, Haryana, India.
Ann Med Surg (Lond). 2019 Jun 21;44:29-32. doi: 10.1016/j.amsu.2019.06.010. eCollection 2019 Aug.
Small cell neuroendocrine carcinoma (NEC) that originates in the tonsil is extremely rare and carries a poor prognosis. Only a few cases of this tumor have been reported so far and the standard treatment protocol remains uncertain.
Here, we describe a 65-year-old woman presenting with throat pain. Computed tomography (CT) scan revealed a mass with moderate enhancement in the right tonsil. A biopsy of the tonsillar mass was performed and histologic examination revealed small round to oval tumor cells arranged in cords or nests, containing hyperchromatic nuclei and scant cytoplasm. Mitotic figures were readily identified. Immunohistochemical staining further corroborated the diagnosis. A diagnosis of primary small cell NEC of the left tonsil was rendered. The patient was treated by six cycles of cisplatin combined with etoposide and the masses showed initial complete response. We also provide a succinct review of all tonsillar SCC cases reported in the English literature and their outcomes.
Small Cell Carcinoma of the tonsil is an extremely rare entity with an aggressive disease course and poor prognosis. Therefore, it is important for the clinicians to be aware of the uncommon occurrence of this disease and its management.
起源于扁桃体的小细胞神经内分泌癌（NEC）极为罕见，预后较差。迄今为止，仅有少数该肿瘤病例被报道，且标准治疗方案仍不明确。
在此，我们描述一名65岁出现咽痛的女性。计算机断层扫描（CT）显示右侧扁桃体有一中等强化肿块。对扁桃体肿块进行活检，组织学检查显示小圆形至椭圆形肿瘤细胞呈条索状或巢状排列，细胞核深染，胞质稀少。可见有丝分裂象。免疫组化染色进一步证实了诊断。确诊为左侧扁桃体原发性小细胞NEC。患者接受了六个周期的顺铂联合依托泊苷治疗，肿块最初显示完全缓解。我们还简要回顾了英文文献中报道的所有扁桃体鳞状细胞癌病例及其结果。
扁桃体小细胞癌是一种极为罕见的疾病，病程侵袭性强，预后不良。因此，临床医生了解这种罕见疾病的发生情况及其治疗方法很重要。
