State University of New York at Potsdam, Department of Chemistry, Potsdam, New York, USA.
Chem Commun (Camb). 2011 Jan 14;47(2):731-3. doi: 10.1039/c0cc03454a. Epub 2010 Nov 8.
Tridentate chelate ligands of 2,6-bis[hydroxy(methyl)amino]-1,3,5-triazine family rapidly release iron from human recombinant ferritin in the presence of oxygen. The reaction is inhibited by superoxide dismutase, catalase, mannitol and urea. Suggested reaction mechanism involves reduction of the ferritin iron core by superoxide anion, diffusion of iron(II) cations outside the ferritin shell, and regeneration of superoxide anions through oxidation of iron(II) chelate complexes with molecular oxygen.
三齿螯合配体家族的 2,6-双[羟甲基（甲）氨基]-1,3,5-三嗪可在有氧存在的情况下迅速从人重组铁蛋白中释放铁。该反应可被超氧化物歧化酶、过氧化氢酶、甘露醇和尿素抑制。建议的反应机制涉及超氧阴离子还原铁蛋白铁核、铁(II)阳离子在铁蛋白壳外扩散，以及通过铁(II)螯合物与分子氧氧化再生超氧阴离子。
