铑/二烯催化的 N-磺酰基吲哚亚胺不对称芳基化：高光学活性的 α-芳基 3-吲哚基甲胺的新途径。
Rhodium/diene-catalyzed asymmetric arylation of N-sulfonyl indolylimines: a new access to highly optically active α-aryl 3-indolyl-methanamines.
机构信息
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
出版信息
Chem Commun (Camb). 2010 Dec 28;46(48):9223-5. doi: 10.1039/c0cc04086j. Epub 2010 Nov 8.
PMID:21060928
Abstract
A new and efficient method for the preparation of highly enantiomerically enriched α-aryl 2- or 3-indolyl-methanamines by rhodium-catalyzed asymmetric arylation of N-sulfonyl indolylimines with arylboronic acids using chiral bicyclo[3.3.0] diene was developed.
摘要
发展了一种新的、高效的方法，通过手性双环[3.3.0]二烯铑催化不对称芳基化 N-磺酰基吲哚亚胺与芳基硼酸，制备高度对映体富集的α-芳基 2-或 3-吲哚基甲胺。
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