利用Man(9)(GlcNAc)(2)-DC-SIGN配对来探究光化学固定中的特异性。
Using the Man(9)(GlcNAc)(2)-DC-SIGN pairing to probe specificity in photochemical immobilization.
作者信息
Dilly Suzanne J, Clark Andrew J, Mitchell Daniel A, Marsh Andrew, Taylor Paul C
机构信息
Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
出版信息
Mol Biosyst. 2011 Jan;7(1):116-8. doi: 10.1039/c0mb00118j. Epub 2010 Nov 9.
PMID:21060950
Abstract
We demonstrate the expected preference of an immobilised oligosaccharide Man(9)(GlcNAc)(2) upon a 96-well photochemical array, for its known receptor, the cell-surface lectin Dendritic Cell-Specific ICAM3 Grabbing Nonintegrin (DC-SIGN) when compared to immobilised competing monosaccharides.
摘要
我们证明了固定在96孔光化学阵列上的低聚糖Man(9)(GlcNAc)(2)，与其已知受体——细胞表面凝集素树突状细胞特异性ICAM3结合非整合素（DC-SIGN）相比，对固定化竞争性单糖的预期偏好。
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