Moguilevsky J A, Justo G, Justo S, Szwarcfarb B, Carbone S, Scacchi P
Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Neuroendocrinology. 1990 Feb;51(2):197-201. doi: 10.1159/000125337.
The administration of 5-hydroxytryptophan (5-HTP) induced a prolactin release in male and female prepubertal rats at 20 days of age. This response was significantly higher in male than in female rats. Neonatal androgenization of the females significantly increased the release of prolactin induced by 5-HTP treatment compared to the values observed in males; thus, the neonatal exposure to androgens seems to be responsible for the sexual differences in the prolactin response to 5-HTP. In a second series of experiments the effect of this serotoninergic precursor on prolactin release in prepubertal (16, 26, and 30 days of age), peripubertal (45-day-old) and adult male rats was studied. Castration significantly decreased the prolactin release response to 5-HTP in prepubertal rats. The administration of testosterone to castrated rats markedly increased the prolactin release response to 5-HTP. Neither castration nor testosterone administration modified the prolactin response to 5-HTP in peripubertal and adult rats. These results appear to indicate that testosterone modulates the serotoninergic control of prolactin secretion during the prepubertal stage. The control of prolactin levels could be one of the mechanisms by which testosterone participates in the sexual maturation.
给20日龄的雄性和雌性青春期前大鼠注射5-羟色氨酸（5-HTP）可诱导催乳素释放。这种反应在雄性大鼠中显著高于雌性大鼠。与雄性大鼠相比，雌性大鼠新生儿期雄激素化显著增加了5-HTP处理诱导的催乳素释放；因此，新生儿期暴露于雄激素似乎是催乳素对5-HTP反应存在性别差异的原因。在第二系列实验中，研究了这种5-羟色胺能前体对青春期前（16、26和30日龄）、青春期前后（45日龄）和成年雄性大鼠催乳素释放的影响。阉割显著降低了青春期前大鼠对5-HTP的催乳素释放反应。给阉割大鼠注射睾酮显著增加了对5-HTP的催乳素释放反应。阉割和注射睾酮均未改变青春期前后和成年大鼠对5-HTP的催乳素反应。这些结果似乎表明，睾酮在青春期前阶段调节5-羟色胺能对催乳素分泌的控制。催乳素水平的控制可能是睾酮参与性成熟的机制之一。
