Moguilevsky J A, Faigón M R, Scacchi P, Szwarcfarb B
Neuroendocrinology. 1987 Apr;45(4):274-7. doi: 10.1159/000124740.
5-hydroxytryptophan (5-HTP), a serotonin precursor, has been shown to induce LH release in female but not in male rats at 16, 18 and 20 days of age. The purpose of this study was to investigate the role of neonatal gonadal hormones on 5-HTP-induced LH release in male and female rats of 16 and 20 days of age. The following groups of rats were studied control females, androgenized females, control males, and castrated males. Androgenization and castration were performed within 48 h of birth. 5-HTP administration increased LH concentration in normal females and castrated males at 16 and 20 days of age. The LH release response to 5-HTP was significantly lower at 20 than at 16 days of age in both groups. Neonatal androgenization abolished the LH release response in prepubertal female rats. These results indicate that neonatal exposure to androgen is responsible for the sex difference in the LH response to 5-HTP, which may be associated with a regulatory action of serotonin on the cyclic hypothalamic control of gonadotrophin secretion.
5-羟色氨酸（5-HTP）是一种血清素前体，已证明在16、18和20日龄的雌性大鼠中可诱导促黄体生成素（LH）释放，但在雄性大鼠中则不然。本研究的目的是探讨新生期性腺激素对16和20日龄雄性和雌性大鼠中5-HTP诱导的LH释放的作用。研究了以下几组大鼠：对照雌性、雄激素化雌性、对照雄性和去势雄性。雄激素化和去势在出生后48小时内进行。在16和20日龄时，给予5-HTP可增加正常雌性和去势雄性大鼠的LH浓度。两组中，20日龄时对5-HTP的LH释放反应均显著低于16日龄时。新生期雄激素化消除了青春期前雌性大鼠的LH释放反应。这些结果表明，新生期接触雄激素是LH对5-HTP反应存在性别差异的原因，这可能与血清素对促性腺激素分泌的周期性下丘脑控制的调节作用有关。
