拉戈唑的简洁全合成。
Concise total synthesis of largazole.
作者信息
Xiao Qiong, Wang Li-Ping, Jiao Xiao-Zhen, Liu Xiao-Yu, Wu Qian, Xie Ping
机构信息
Peking Union Medical College & Chinese Academy of Medical Sciences, Institute of Materia Medica, Beijing, China.
出版信息
J Asian Nat Prod Res. 2010 Nov;12(11):940-9. doi: 10.1080/10286020.2010.510114.
PMID:21061215
Abstract
The concise total synthesis of largazole was accomplished. The key step included the use of the Nagao thiazolidinethione auxiliary for the diastereoselective acetate aldol reaction and it acts as an acylating agent for the peptide formation.
摘要
完成了拉戈唑的简洁全合成。关键步骤包括使用长谷硫代噻唑烷辅助剂进行非对映选择性乙酸酯羟醛反应，并且它在肽形成过程中充当酰化剂。
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