Asa S L, Kovacs K, Stefaneanu L, Horvath E, Billestrup N, Gonzalez-Manchon C, Vale W
Department of Pathology, St. Michael's Hospital, University of Toronto, Ontario, Canada.
Proc Soc Exp Biol Med. 1990 Mar;193(3):232-5. doi: 10.3181/00379727-193-3-rc1.
It has been shown that mice transgenic for human growth hormone-releasing hormone (GRH) develop hyperplasia of pituitary somatotrophs and mammosomatotrophs, cells capable of producing both growth hormone and prolactin, by 8 months of age. We now report for the first time that old GRH-transgenic mice, 16 to 24 months of age, develop pituitary mammosomatotroph adenomas. These findings provide conclusive evidence that protracted stimulation of secretory activity can cause proliferation, hyperplasia and adenoma of adenohypophysial cells.
研究表明，转人类生长激素释放激素（GRH）基因的小鼠在8月龄时，垂体生长激素细胞和泌乳生长激素细胞会发生增生，这些细胞能够同时产生生长激素和催乳素。我们首次报告，16至24月龄的老年GRH转基因小鼠会发生垂体泌乳生长激素细胞腺瘤。这些发现提供了确凿的证据，即分泌活动的长期刺激可导致腺垂体细胞的增殖、增生和腺瘤形成。
