Mekhtiev A A, Palatnikov G M, Movsum-zade S K, Kasimov R Iu
Zh Evol Biokhim Fiziol. 2010 Sep-Oct;46(5):375-9.
The work present data on studies of a decreased activity of serotoninergic system on the level of mutagenic changes (the micronuclear test) in the goby Neogobius fluviatilis and the fry if sturgeon Acipenser güldenstädti persicus. It has been shown that the long exposure of the animals to conditions of industrial and oil pollution leads to a significant decrease in their liver of the level of serotonin-modulated anticonsolidation protein (SMAP) correlating directly with the serotonin level as well as to sharp increase of the level of micronuclei in erythrocytes. The intramuscular administration of anti-SMAP polyclonal antibodies to the fry of the sturgeon produces a significant increase of the amount of micronuclei as compared with that in the animals injected with non-immune gamma-globulin. The obtained results allow concluding that the decrease of activity of the serotoninergic system is the mechanism that is triggered with adverse environmental factors and realizes mutagenic damages in the modified genetic apparatus.
该研究呈现了关于河鲈（Neogobius fluviatilis）和俄罗斯鲟（Acipenser güldenstädti persicus）幼鱼中，血清素能系统活性降低对诱变变化水平（微核试验）影响的研究数据。结果表明，动物长期暴露于工业污染和石油污染环境中，会导致其肝脏中血清素调节的抗巩固蛋白（SMAP）水平显著下降，而该水平与血清素水平直接相关，同时红细胞中的微核水平急剧增加。对鲟鱼幼鱼肌肉注射抗SMAP多克隆抗体后，与注射非免疫γ-球蛋白的动物相比，微核数量显著增加。所得结果表明，血清素能系统活性降低是由不利环境因素引发的机制，会在遗传物质发生改变时导致诱变损伤。
