美拉尼西亚的α+地中海贫血与疟疾：流行病学视角
Alpha+ -thalassaemia and malaria in Melanesia: epidemiological perspectives.
作者信息
Fowkes Freya J I, Day Karen P
机构信息
Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
出版信息
P N G Med J. 2008 Sep-Dec;51(3-4):131-7.
In 1948 Haldane first proposed that the high frequencies of thalassaemias in malaria-endemic regions were due to natural selection by malaria. Some of the highest frequencies of alpha+ -thalassaemia are found in the Pacific region of Melanesia. Consequently, Melanesia has provided a unique opportunity for an extensive study of the association between alpha+ -thalassaemia and malaria. Here we review the emergence of alpha+ -thalassaemia in this region and the research that has been carried out, both from the historical perspective and the most recent developments, which may give insight into the selection of alpha+ -thalassaemia by malaria.
1948年，霍尔丹首次提出，疟疾流行地区地中海贫血的高发病率是由疟疾的自然选择所致。α+地中海贫血的一些最高发病率出现在美拉尼西亚的太平洋地区。因此，美拉尼西亚为广泛研究α+地中海贫血与疟疾之间的关联提供了独特的机会。在此，我们从历史角度和最新进展两方面回顾该地区α+地中海贫血的出现情况以及已开展的研究，这些研究可能有助于深入了解疟疾对α+地中海贫血的选择作用。
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