高频率的α地中海贫血是疟疾自然选择的结果。
High frequencies of alpha-thalassaemia are the result of natural selection by malaria.
作者信息
Flint J, Hill A V, Bowden D K, Oppenheimer S J, Sill P R, Serjeantson S W, Bana-Koiri J, Bhatia K, Alpers M P, Boyce A J
出版信息
Nature. 1986;321(6072):744-50. doi: 10.1038/321744a0.
DOI:10.1038/321744a0
PMID:3713863
Abstract
The frequency of alpha+-thalassaemia, but not other unlinked DNA polymorphisms, exhibits an altitude- and latitude-dependent correlation with malaria endemicity throughout Melanesia, supporting the hypothesis that protection against this parasitic disease is the major factor responsible for the high frequencies of haemoglobinopathies in many parts of the world.
摘要
在美拉尼西亚，α+地中海贫血的发生频率，而非其他不连锁的DNA多态性，呈现出与疟疾流行程度相关的海拔和纬度依赖性，这支持了以下假说：抵御这种寄生虫病是世界许多地区血红蛋白病高发的主要原因。
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