α地中海贫血与疟疾假说
Alpha-thalassaemia and the malaria hypothesis.
作者信息
Hill A V, Flint J, Weatherall D J, Clegg J B
机构信息
MRC Molecular Haematology Unit, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, UK.
出版信息
Acta Haematol. 1987;78(2-3):173-9. doi: 10.1159/000205870.
PMID:3120467
Abstract
Recent population genetic studies of the distribution of alpha+-thalassaemia in Melanesia using DNA analysis have provided strong support for the hypothesis that high frequencies of this genetic disorder are the result of natural selection by malaria.
摘要
最近利用DNA分析对美拉尼西亚地区α+地中海贫血分布情况进行的群体遗传学研究，为这一遗传病的高发病率是由疟疾自然选择所致的假说提供了有力支持。
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