Argiolu F, Diana G, Arnone M, Batzella M G, Piras P, Cao A
Istituto di Clinica e Biologia dell'Età Evolutiva, Università degli Studi, S. Gavino, Italia.
Acta Haematol. 1990;83(2):65-8. doi: 10.1159/000205170.
Patients with thalassemia major due to red blood cell autoantibodies may develop an increase in transfusional blood consumption. In this study we report the results of treatment with high intravenous immunoglobulin (Ig) in 4 patients who developed an increase in blood consumption related to the presence of autoantibodies of defined or undefined specificities. Three patients showed a normalization of the blood consumption. No adverse effects were detected. These results indicate that high-dose intravenous Ig therapy is indicated in patients with thalassemia major manifesting an increase in blood consumption following the development of red cell autoantibodies.
由于红细胞自身抗体导致的重型地中海贫血患者可能会出现输血用血量增加的情况。在本研究中，我们报告了4例因存在明确或不明确特异性自身抗体而导致用血量增加的患者接受高剂量静脉注射免疫球蛋白（Ig）治疗的结果。3例患者的用血量恢复正常。未检测到不良反应。这些结果表明，对于红细胞自身抗体出现后表现出用血量增加的重型地中海贫血患者，高剂量静脉注射Ig治疗是有效的。
