Department of Chemistry, University of California, Berkeley, California 94720, United States.
J Am Chem Soc. 2010 Dec 1;132(47):16771-3. doi: 10.1021/ja108898t. Epub 2010 Nov 9.
A highly active heterogeneous Pd-nanoparticle catalyst for the intramolecular addition of phenols to alkynes was developed and employed in a continuous flow reaction system. Running the reaction in flow mode revealed reaction kinetics, such as the activation energy and catalyst deactivation, and provides many potential practical advantages.
开发了一种用于酚类化合物与炔烃分子内加成的高效非均相 Pd 纳米粒子催化剂，并将其应用于连续流动反应体系中。在流动模式下进行反应揭示了反应动力学，如活化能和催化剂失活，并提供了许多潜在的实际优势。
