Hirano T, Tsuchiyama H, Yanagawa M
Acta Pathol Jpn. 1978 May;28(3):465-9. doi: 10.1111/j.1440-1827.1978.tb01270.x.
Au autopsy case of cholangiocarcinoma which showed clinically hypercalcemia and hypophosphatemia without bone metastases is presented in this report. Although parathyroid hormone (PTH)-like substance of 520 ng/g. dry weight was measured in neoplastic tissue by the radioimmunoassay, membrane-limited secretory granules as those of parathyroid gland were not found in the fine structure. The significance of an existence of secretory granules in ectopic PTH producing tumor is discussed.
本文报告一例胆管癌尸检病例，该病例临床出现高钙血症和低磷血症，但无骨转移。尽管通过放射免疫测定法在肿瘤组织中测得甲状旁腺激素（PTH）样物质为520 ng/g干重，但在超微结构中未发现甲状旁腺那样的膜性分泌颗粒。本文还讨论了异位产生PTH的肿瘤中分泌颗粒存在的意义。
